Frontiers in psychiatry

How letting go, distancing, and rethinking relate to psilocybin response in hard-to-treat OCD

Psychedelic Science Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated

Abstract

Psilocybin treatment has shown promise for treatment-resistant obsessive-compulsive disorder (OCD).

  • Clinical response to psilocybin in OCD varies among individuals.
  • Subjective experiences linked to treatment outcomes remain poorly understood.
  • Psychological processes may differentiate responders from non-responders.

Simplified

Full Text

Full text is available at the source.
View Full Text ↗

Related papers

Dec '25
Immediate and lasting effects of a single psilocybin dose for obsessive-compulsive disorder in a controlled clinical trial
top 20% journal
cited by 5 papers
journal article
Jan '26
Psilocybin treatment for PTSD: participant experiences, trauma processing, and how it differs from standard therapy
top 2% journal
cited by 3 papers
journal article
Jan '26
How reflections after a psychedelic session relate to 3-month drinking abstinence in people with alcohol use disorder and depression
top 5% journal
journal article
Mar '26
Repeated psilocybin doses for treating obsessive-compulsive disorder in a clinical trial
top 10% journal
journal article

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the psychedelic science brief

issue #53
One psilocybin session held antidepressant effects for 52 weeks in a new follow-up study
2 weeks ago7 studies
issue #52
Psilocybin didn't create disorder in the brain — it created a different kind of order
3 weeks ago7 studies
issue #51
Psilocybin worked for treatment-resistant depression in real Swiss clinics — not just controlled trials
4 weeks ago7 studies
issue #50
Psilocybin beat placebo on depression scores in an NHS trial — by a lot
5 weeks ago7 studies
issue #49
Psilocybin stays active in neurons long after it leaves the bloodstream — here's what that means
6 weeks ago7 studies
issue #48
Psychedelics during adolescence reshaped adult social behavior in rats — here's the circuit
7 weeks ago7 studies
issue #47
Psilocybin rewired prefrontal circuits in mice — but only for one specific type of cognitive failure
8 weeks ago7 studies
issue #46
Psilocybin cut two specific brain chemicals in depressed patients — here's what that means
9 weeks ago7 studies
issue #44
Psilocybin rewires brain feedback circuits for weeks after a single dose, new evidence shows
10 weeks ago7 studies
issue #43
A pill form of ketamine cut dissociation to near-zero vs. nasal spray's 29.6-point spike — but missed its main antidepressant target
11 weeks ago7 studies
explore the archive
See more issues from the psychedelic science brief