How a psychedelic drug changes mice’s sense of smell and searching behavior

The psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) decreases search accuracy in mice during olfactory tasks.

• DOI alters movement patterns in mice when performing olfactory search tasks.
• Mice exhibit an increased sniff rate following administration of DOI.
• These results indicate that DOI may disrupt behaviors guided by the sense of smell.

Simplified