Journal of psychopharmacology (Oxford, England)

Finding the best dose for psychedelics to reduce fear in rodent studies

Updated

Abstract

Individuals with anxiety and stress-related disorders frequently demonstrate impaired threat extinction.

  • Psilocybin, LSD, DMT, MDMA, and ketamine may facilitate fear extinction in rodent models.
  • Comprehensive analyses of these substances' effects on threat extinction are limited.
  • There is a need for integrative studies to better understand the potential of these compounds.

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