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Abstract
Rates of psychedelic-associated dysphoria/euphoria, hypomania, or mania ranged from 5.8% in controlled trials to 30% in naturalistic studies of individuals with bipolar disorder.
- Manic symptoms following serotonergic psychedelics are typically acute and self-limited.
- Higher risks of mood symptoms are observed in individuals with bipolar I disorder, familial vulnerability, polysubstance use, and unsupervised or illegal use.
- Registry-based cohorts show a 4% prevalence of subsequent transition to bipolar disorder among participants.
- There is little evidence for a hallucinogen-specific signal in diagnostic transitions to bipolar disorder.
- Overall, serotonergic psychedelics may pose a low but clinically meaningful relative risk of transient mood-related symptoms in susceptible individuals.
Simplified
Psychedelic Science