Novel psychedelic interventions for post-traumatic stress disorder and their promise for precision medicine

Dec 9, 2025Therapeutic advances in psychopharmacology

New psychedelic treatments for post-traumatic stress disorder and their potential for personalized care

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Abstract

Psychedelic compounds such as ketamine, MDMA, and psilocybin may enhance treatment for post-traumatic stress disorder (PTSD).

  • may modulate pathways related to synaptic plasticity, potentially improving memory processing and extinction.
  • Combining psychedelics with existing treatments could enhance the efficacy of current psychotherapies for PTSD.
  • Rapid and lasting improvements in chronic symptoms may be achievable with these novel interventions.
  • Modern prediction methods for treatment response could allow for personalized psychedelic interventions tailored to individual patients.
  • This review identifies limitations in current PTSD treatment and explores the potential of psychedelics and .

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