Psychedelics and Headache Disorders: an Update

Aug 9, 2025Current neurology and neuroscience reports

Psychedelics and Their Relationship to Headache Disorders: An Update

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Abstract

Sub-hallucinogenic doses of psychedelics may provide symptom relief for migraine and cluster headache.

  • Observational data and case reports indicate potential benefits of psychedelics for headache disorders.
  • Recent small controlled trials suggest favorable outcomes for migraine and cluster headache treatment.
  • Safety signals appear generally positive, but concerns exist regarding systemic and psychiatric effects.
  • No new studies have been completed on psychedelics for other headache disorders.
  • Legal complexities hinder access to psychedelic treatments, necessitating further research for confirmation of effectiveness and safety.

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