Psychobiotics for the treatment of neuropsychiatric, neurodegenerative, and neurodevelopmental disorders: A systematic review

Feb 13, 2026Progress in neuro-psychopharmacology & biological psychiatry

Using beneficial gut bacteria to treat mental health, brain aging, and brain development disorders: A systematic review

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Abstract

Psychobiotics may enhance gut-brain communication and have therapeutic potential for various neuropsychiatric disorders.

  • These probiotics can produce neurotransmitters, short-chain fatty acids, and neuroactive hormones.
  • They are associated with regulating brain function and behavior.
  • Clinical trials offer preliminary support for their efficacy in treating neurodevelopmental and neurodegenerative disorders.
  • The exact mechanisms of action of psychobiotics are not fully understood.
  • Challenges exist in study design, patient stratification, and clinical translation for psychobiotic-based interventions.

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