Pu-erh tea, green tea, and black tea suppresses hyperlipidemia, hyperleptinemia and fatty acid synthase through activating AMPK in rats fed a high-fructose diet

Dec 1, 2011Food & function

Pu-erh, green, and black teas reduce high blood fat, leptin levels, and fat production by activating energy regulation in rats fed high fructose

AI simplified

PubMed ↗DOI ↗

Abstract

Consuming green, black, and pu-erh tea leaves for 12 weeks significantly reduced serum triacylglycerols and cholesterol levels in rats fed a high-fructose diet.

A fructose-rich diet elevated serum triacylglycerols, cholesterol, insulin, and leptin concentrations compared to the control group.
Rats consuming green tea and pu-erh tea showed the greatest reduction in serum triacylglycerols, cholesterol, insulin, and leptin levels.
The relative weight of epididymal adipose tissue was lower in all tea-supplemented rats compared to those fed only fructose.
Molecular analysis indicated improved lipid balance through reduced fatty acid synthase protein expression.
Green, black, and pu-erh tea supplementation decreased hepatic fatty acid synthase mRNA and protein levels and increased AMPK phosphorylation.

AI simplified

Although green tea extract has been reported to suppress hyperlipidemia, it is unclear how tea extracts prepared from green, oolong, black and pu-erh teas modulate fatty acid synthase expression in rats fed on a high-fructose diet. In this animal study, we evaluated the hypolipidemic and hypoleptinemia effect of these four different tea leaves fed to male Wistar rats for 12 weeks. The results showed that a fructose-rich diet significantly elevated serum triacylglycerols, cholesterol, insulin, and leptin concentrations, as compared with those in the control group. Interestingly, consuming tea leaves for 12 weeks almost normalized the serum triacylglycerols concentrations. Again, rats fed with fructose/green tea and fructose/pu-erh tea showed the greatest reduction in serum TG, cholesterol, insulin and leptin levels. In contrast, serum cholesterol and insulin concentrations of the fructose/oolong tea-fed rats did not normalize. The relative epididymal adipose tissue weight was lower in all rats supplemented with tea leaves than those fed with fructose alone. There was molecular evidence of improved lipid homeostasis according to fatty acid synthase (FAS) protein expression. Furthermore, supplementation of green, black, and pu-erh tea leaves significantly decreased hepatic FAS mRNA and protein levels, and increased AMPK phosphorylation, compared with those of rats fed with fructose only. These findings suggest that the intake of green, black, and pu-erh tea leaves ameliorated the fructose-induced hyperlipidemia and hyperleptinemia state in part through the suppression of FAS protein levels and increased AMPK phosphorylation.

Full Text

Full text is available at the source.

View full text ↗

Abstract

Full Text

Related papers

what lands in your inbox each week: