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Efficacy and Safety of Pyronaridine-Artesunate plus Single-Dose Primaquine for the Treatment of Malaria in Western Cambodia
Effectiveness and Safety of Pyronaridine-Artesunate with a Single Dose of Primaquine for Treating Malaria in Western Cambodia
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Abstract
Efficacy of a 3-day treatment with pyronaridine-artesunate plus primaquine reached 98.3% in one trial location.
- The trial included 104 participants treated for malaria in western Cambodia.
- At Day 42, the PCR-adjusted adequate clinical and parasitological response (ACPR) was 98.3% in Trapeng Chau and 100% in Veal Veng.
- Day 28 ACPR for pyronaridine-artesunate was also high, with rates of 98.3% and 100% at the respective locations.
- Approximately 80.6% of patients presented with drug resistance molecular markers.
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