Quality of sleep in young onset Parkinson's disease: Any difference from older onset Parkinson's disease

Mar 7, 2015Parkinsonism & related disorders

Sleep quality in young-onset versus older-onset Parkinson's disease

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Abstract

Insomnia was reported in 55.2% of patients with older onset Parkinson's disease compared to 27.5% in those with young onset Parkinson's disease.

Patients with young onset Parkinson's disease (YOPD) experienced fewer instances of insomnia than those with older onset Parkinson's disease (OOPD).
Nightmares occurred less frequently in YOPD patients (7.8%) compared to OOPD patients (24.8%).
YOPD patients reported a higher mean number of actual sleep hours per night.
The global sleep quality score was better for YOPD patients, indicating overall improved sleep quality.
Daytime sleepiness was significantly lower in YOPD patients compared to OOPD patients.

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BACKGROUND: Sleep disorders occur commonly in Parkinson's disease and are often under-recognized and under treated in clinical practice.

OBJECTIVES: To determine the quality of sleep in patients with Young onset Parkinson's disease (YOPD) and to note whether there is any difference in quality of sleep from those patients with older onset Parkinson's disease (OOPD).

METHODS: One hundred and fifty six patients with Parkinson's disease (YOPD-51, OOPD-105) were clinically examined and quality of sleep was determined using Pittsburgh sleep quality index (PSQI), Parkinson's disease Sleep Scale (PDSS) and Epworth Sleep Scale (ESS). Other scales included Uniﬁed Parkinson's Disease Rating Scale -part III (UPDRS-III), Hoehn & Yahr Stage, Mini Mental Status Examination, Hamilton anxiety rating scale and Hamilton depression rating scale.

RESULTS: The frequency of insomnia was higher in OOPD (55.2%) as compared to YOPD (27.5%) group (p = 0.001). The frequency of nightmares was lower in YOPD (7.8%) when compared to OOPD (24.8%) group (p = 0.012). The mean hours of actual sleep per night were higher in YOPD patients. Global PSQI score was better in YOPD indicating good overall sleep quality in YOPD patients. The total ESS score was significantly lower in YOPD (p = 0.019). The total PDSS score was significantly better in YOPD patients (p = 0.018).

CONCLUSIONS: Patients with YOPD had an overall better quality of sleep with lesser incidence of insomnia, nightmares, daytime sleepiness and restlessness during sleep.

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Quality of sleep in young onset Parkinson's disease: Any difference from older onset Parkinson's disease

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