Frontiers in pharmacologyOct 23, 2026

Quercetin increases TLE4 to block a cell growth pathway and reduce cervical cancer cell movement and spread

CRISPR Gene Editing Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Oct 24, 2026

Abstract

TLE4 was verified to have a biological function in cervical cancer using cell lines and mouse models.

TLE4 overexpression and CRISPR-Cas9 knockout techniques were applied to cervical cancer cell lines.
Nude mouse models were utilized to study tumor formation related to TLE4.
The research aimed to clarify the regulatory mechanisms involving TLE4 in cervical cancer.

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