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RETRACTED: The RasGAP-associated endoribonuclease G3BP assembles stress granules
The protein G3BP helps build stress granules in cells
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Abstract
G3BP, a protein involved in stress granule assembly, is recruited in cells exposed to arsenite.
- Stress granules form in response to various toxic agents and play a role in mRNA metabolism during stress.
- G3BP is a phosphorylation-dependent endoribonuclease that interacts with RasGAP and is linked to mRNA fate during stress.
- Overexpression of G3BP can induce stress granule assembly, while a specific domain of G3BP can inhibit this process.
- Arsenite treatment induces the dephosphorylation of serine 149 on G3BP, affecting its ability to oligomerize and form stress granules.
- A mutant form of G3BP that mimics phosphorylation (S149E) cannot assemble stress granules, whereas a nonphosphorylatable mutant (S149A) can.
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