Advanced science (Weinheim, Baden-Wurttemberg, Germany)Aug 27, 2026

The RNA-Binding Protein RBMS1 Helps Blood Vessel Lining Cells Clean Themselves to Keep Vessels Healthy and Prevent Deep Vein Blood Clots

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Aug 28, 2026

Abstract

RBMS1 deficiency in a mouse model is associated with increased thrombus formation and impaired endothelial cell function.

RNA-binding proteins, particularly RBMS1, may play a significant role in the development of deep vein thrombosis (DVT).
In mice lacking RBMS1 specifically in endothelial cells, thrombus formation is exacerbated.
RBMS1 is linked to the stability of autophagy-related 3 (ATG3) mRNA, which is crucial for maintaining autophagy in vascular endothelial cells.
Loss of RBMS1 leads to destabilization of ATG3 mRNA, resulting in reduced autophagic activity and compromised endothelial integrity.
Overexpression of ATG3 can counteract the negative effects of RBMS1 depletion, suggesting a potential pathway for therapeutic intervention.

Simplified

Deep vein thrombosis (DVT) is a prevalent vascular disorder characterized by aberrant coagulation within the deep venous system, and the roles of RNA-binding proteins (RBPs) in its pathogenesis remain largely undefined. Herein, using a murine inferior vena cava (IVC) stenosis model, we identify RNA-binding motif single-stranded interacting protein 1 (RBMS1) as a previously unrecognized regulator of DVT progression via the modulation of vascular endothelial cell (VEC) autophagy. By utilizing endothelial cell-conditional Rbms1 knockout mice, we demonstrate that RBMS1 deficiency exacerbates thrombus formation and impairs VEC function. Mechanistically, RBMS1 associates with autophagy-related 3 (ATG3) mRNA through its 3'-untranslated region (3'-UTR) and enhances its stability, thereby promoting autophagic flux in VECs. RBMS1 depletion destabilizes ATG3 mRNA, leading to suppressed autophagy and compromised endothelial homeostasis. Conversely, ATG3 overexpression rescues autophagy impairment and mitigates thrombotic phenotypes upon RBMS1 depletion. Collectively, our findings in the IVC stenosis-induced DVT model demonstrate that RBMS1 regulates ATG3 to maintain vascular endothelial integrity, providing a mechanistic basis for further evaluation of RBMS1 in DVT intervention.

Full Text

Full text is available at the source.

View Full Text ↗

The RNA-Binding Protein RBMS1 Helps Blood Vessel Lining Cells Clean Themselves to Keep Vessels Healthy and Prevent Deep Vein Blood Clots

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

What Lands in Your Inbox Each Week:

Recent issues from the longevity & aging brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

What Lands in Your Inbox Each Week:

Recent issues from the longevity & aging brief