Obesity surgeryOct 18, 2025

Repeated Weight Gain After Sleeve Gastrectomy: Is Switching to Duodenal Switch Better Than Roux-en-Y Gastric Bypass?

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗

Updated Mar 19, 2026

Abstract

Conversion from Sleeve Gastrectomy to Duodenal Switch resulted in a 33% total weight loss at 24 months, compared to 19% for Roux-en-Y Gastric Bypass.

100 patients underwent conversion due to recurrent weight gain, with 90 opting for Roux-en-Y Gastric Bypass and 10 for Duodenal Switch.
Duodenal Switch patients had a higher preoperative body mass index (BMI) of 57.2 kg/m compared to 38.9 kg/m for those undergoing Roux-en-Y Gastric Bypass.
Operative time was shorter for the Duodenal Switch group, averaging 142.5 minutes versus 193.8 minutes for Roux-en-Y Gastric Bypass.
Both groups had similar lengths of hospitalization and comparable late reoperation rates (14.4% for Roux-en-Y versus 20% for Duodenal Switch).
Duodenal Switch demonstrated significantly greater total weight loss percentages at 6, 12, and 24 months compared to Roux-en-Y Gastric Bypass.

Simplified

BACKGROUND: Rates of conversion procedures after Sleeve Gastrectomy have been reported to reach up to 12.2% in 10 years of follow-up. The aim of this study was to compare perioperative outcomes and weight changes in patients who underwent either conversion from SG to Roux-en-Y Gastric Bypass (C-RYGB) or Duodenal Switch (C-DS).

METHODS: This study was a nonrandomized, controlled, retrospective review of 100 patients who underwent conversion of LSG due to recurrent weight gain at our institution from May 2015 to November 2024. Perioperative and postoperative variables were examined.

RESULTS: Of 481 SGs, 100 patients (90 C-RYGB; 10 C-DS) underwent conversion due to recurrent weight gain. The C-DS group had a higher preoperative BMI compared to C-RYGB (57.2 kg/mvs 38.9 kg/m, p < 0.001). Additionally, C-DS showed shorter operative time (142.5 min vs 193.8 min, p = 0.02) and similar length of hospitalization than C-RYGB. There was no significant difference in late reoperation rate between groups (13 [14.4%] C-RYGB vs 2 [20%] C-DS). The C-DS group had significant differences in %TWL at 6-,12- and 24-month follow-up with values of 21% vs 15.5%, 30% vs 18.2% and 33% vs 19% over C-RYGB, respectively. Excess preoperative BMI at the time of conversion was associated with a greater weight loss (each 1 kg/mincrease yielded 0.7% greater %TWL). However, no significant correlation was found between these two variables (p = 0.24, R = 0.05). 2 2 2 2

CONCLUSIONS: C-DS appears to be safe and feasible for the surgical management of recurrent weight gain after LSG. In addition, C-DS provides a significantly higher %TWL on 6, 12 and 24 months compared to C-RYGB.

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Declarations. Ethical Approval: For this type of study, formal consent is not required. Informed Consent: Informed consent does not apply. Conflict of interest: The authors declare no competing interests.

PubMed

Repeated Weight Gain After Sleeve Gastrectomy: Is Switching to Duodenal Switch Better Than Roux-en-Y Gastric Bypass?

Abstract

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Abstract

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