Rejuvenation Potential of Developmental Genes Downregulated in Aging
Rejuvenation Potential of Genes Active in Development That Decrease with Aging
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Abstract
Four rejuvenation induction factors (RIFs) were identified that may offer a safer alternative to Yamanaka factors for reversing cellular aging.
- RIFs were isolated based on genes that are downregulated with aging and upregulated during development.
- The identified RIFs are linked to ribosome biogenesis, mitochondrial import, translational regulation, and serine metabolism.
- In aged fibroblasts, RIF expression led to a reduction in senescence markers.
- RIFs increased gene expression patterns that are inversely associated with changes typically seen in aging.
- These RIFs do not activate pluripotency-associated programs, suggesting a different mechanism than Yamanaka factors.
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