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Comparison of the effects of remimazolam tosylate and propofol on postoperative delirium among older adults undergoing major non-cardiac surgery: protocol for a randomised controlled trial
Comparing remimazolam tosylate and propofol for postoperative delirium in older adults after major non-heart surgery
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Abstract
A total of 636 elderly patients will be enrolled to evaluate the incidence of after anesthesia with either remimazolam tosylate or propofol.
- Postoperative delirium (POD) is characterized by acute and fluctuating impairments in attention and awareness.
- This study aims to assess the incidence of POD within 5 days following major non-cardiac surgery.
- Patients will be randomized in a 1:1 ratio to receive total intravenous anesthesia with either remimazolam tosylate or propofol.
- Secondary outcomes include the onset and duration of delirium, cognitive function at discharge and 1 year postoperatively, and postoperative inflammatory biomarker levels.
- Delirium will be assessed twice daily using a standardized diagnostic interview method.
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Key numbers
5.7% to 71%
Incidence of in elderly patients
Reported incidence rates of after major surgery in elderly patients.
636
Number of patients enrolled
Total number of elderly patients planned for enrollment in the study.