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Renoprotective effects of brown adipose tissue activation in diabetic mice
Kidney-protecting effects of activating brown fat in diabetic mice
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Abstract
activation significantly decreased 24-hour urinary albumin from 70.46 ± 15.81 μg/24 h to 34.21 ± 6.28 μg/24 h (P < 0.05) in diabetic mice.
- Activation of brown adipose tissue (BAT) reduced blood glucose levels, showing a decrease from 23.60 ± 3.90 mM to 20.58 ± 3.55 mM, although this was not statistically significant.
- Triglycerides and low-density lipoprotein cholesterol levels were significantly decreased, while high-density lipoprotein cholesterol levels increased following BAT activation.
- Renal pathology showed improvements, with reduced fibrosis, inflammation, and oxidative stress in the kidneys of treated diabetic mice.
- CL316,243 treatment enhanced serum adiponectin levels and renal sensitivity to Fgf21, indicating metabolic benefits.
- The treatment also activated the renal AMPK/Sirt1/Pgc1α signaling pathway and influenced the levels of circulating microRNAs and their target gene expression in the kidneys.
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Key numbers
34.21 ± 6.28 μg/24 h
Decrease in Urinary Albumin Excretion
Urinary albumin levels in diabetic mice treated with CL316,243.
0.53 ± 0.02 mM
Triglycerides Reduction
Triglyceride levels in diabetic mice after activation.
Not quantified
Restoration of Serum Adiponectin
Serum adiponectin concentrations in diabetic mice treated with CL316,243.