Reprogramming cellular senescence and aging clocks for advanced cancer immunotherapy

Oct 3, 2025Molecular cancer

Changing cell aging and timing processes to improve cancer immune treatments

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Longevity & Aging on OpenScience ↗PubMed ↗DOI ↗OA ↗

Abstract

may promote advanced malignant progression through secretory and immunomodulatory functions.

Cellular senescence involves irreversible cell cycle arrest and is regulated by specific pathways.
Senescent cells can recruit immune cells to eliminate new tumors but may also lead to chronic inflammation.
Chronic inflammation from persistent senescent cells is associated with immune escape and fibrosis.
The tumor microenvironment is influenced by senescent cells that secrete pro-inflammatory cytokines.
Aging clocks may help differentiate between biological and chronological aging, impacting individual cancer susceptibility.
Current therapeutic approaches include senolytic agents that target senescent cells to inhibit tumor growth.

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has gradually been recognized as a key process, which not only inhibits the occurrence of early tumors but also promotes advanced malignant progression through secretory and immunomodulatory functions. Initially, cellular senescence manifested as irreversible cell cycle arrest, but now it encompasses a broader phenotype regulated by the p53-p21CIP1 and p16INK4A-Rb pathways. Although secretory phenotypes related to aging can recruit immune effectors to clear new tumor cells, persistent senescent cell populations often trigger chronic inflammation, promoting immune escape and fibrosis. In this review, we first discuss the molecular underpinnings of cellular senescence, highlighting its induction pathways and diverse physiological or pathological roles. We then examine the composition of the tumor microenvironment, where senescent cells accumulate and secrete pro-inflammatory cytokines, reshaping immune surveillance and extracellular matrix architecture. Against this backdrop, we explore how aging clocks refine our understanding of individual susceptibility to malignancy by distinguishing biological from chronological aging. We also present current therapeutic prospects, including senolytic agents targeting senescent stromal cells that promote tumor growth, and the utilization of metrics to tailor immunotherapies more effectively for older patients. Finally, we consider the major challenges facing clinical translation, from standardizing multi-omics data pipelines to clarifying the ethical implications of measuring biological age. By bridging senescence biology with geroscience and cutting-edge oncology, we posit that aging clocks may catalyze a transformation in cancer care, enabling more personalized, effective, and age-conscious treatment strategies.

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Reprogramming cellular senescence and aging clocks for advanced cancer immunotherapy

Abstract

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