Correlation of Resistin Serum Level with Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism in Obese Women with Type 2 Diabetes

Jun 2, 2017Diabetes & metabolic syndrome

Relationship between Resistin Levels, Body Fat, and a Common Obesity Gene in Obese Women with Type 2 Diabetes

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Abstract

Serum resistin concentrations were not significantly different between diabetic and non-diabetic women.

In the diabetic group, resistin levels were lower in women with the AA genotype compared to those with other genotypes.
Insulin and HOMA levels were higher in individuals with the AA genotype of the FTO gene.
Fasting blood sugar and HbA1c levels were elevated in women with AA and AT genotypes.
Triglyceride levels were significantly higher in the TA genotype within the diabetic group.
No significant correlation was found between resistin and most metabolic or anthropometric parameters, except for diastolic blood pressure in diabetic patients.

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AIMS: The aim of this study was to detect any association of fat mass and obesity-associated (FTO) rs9939609 variant to metabolic and anthropometric parameters and resistin level as adipokines in Iranian obese women with type 2 diabetes mellitus.

MATERIAL AND METHODS: Totally, 42 diabetic and 36 non-diabetic women were selected. The PCR amplicons of FTO gene were sequenced and metabolic, anthropometric parameters and resistin level were measured.

RESULTS: Serum resistin concentrations were not different between diabetic and non-diabetic subjects (p>0.05), while resistin level in diabetic group with AA genotype was lower than that with other genotypes in the same group. In rs9939609 SNP adjusted analysis, insulin and HOMA levels were high in AA genotype. While levels of FBS and HbAwere higher in AA and AT genotypes. In diabetic group, only TG showed significant difference among three genotypes and mean of TG was higher in TA genotype. No significant correlation between resistin and anthropometric and metabolic parameters was found except for DBP in diabetic patients. 1c

CONCLUSION: There was no significant association between rs9939609 and resistin serum level in type 2 obese diabetic women while percentile ranges (25, 50and 75) of resistin concentrations was high in diabetic group. th th th

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Correlation of Resistin Serum Level with Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism in Obese Women with Type 2 Diabetes

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