Resveratrol prevents the combined maternal plus postweaning high-fat-diets-induced hypertension in male offspring

Aug 22, 2017The Journal of nutritional biochemistry

Resveratrol may prevent high blood pressure caused by combined maternal and post-weaning high-fat diets in male offspring

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Abstract

Resveratrol prevented hypertension induced by a high-fat diet in adult male offspring.

Maternal high-fat diet may induce oxidative stress and activate signals that increase hypertension risk in offspring.
Offspring from high-fat diet mothers who continued on a high-fat diet exhibited hypertension.
Resveratrol treatment reduced oxidative stress in the kidneys of hypertensive offspring.
The protective effects of resveratrol involved reducing levels of asymmetric dimethylarginine in the kidneys.
Resveratrol influenced the renin-angiotensin system to favor vasodilation.
Increased levels of nutrient-sensing pathways and autophagy were observed with resveratrol treatment.

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Maternal high-fat (HF) diet is believed to induce oxidative stress and activate nutrient-sensing signals, which increase the risk of adult offspring to develop hypertension. We investigated whether resveratrol prevents the combined maternal plus postweaning HF-diets-induced hypertension in adult male offspring, with a focus on the kidney. Female Sprague-Dawley rats received either a normal diet (ND) or HF diet (D12331, Research Diets) for 5 weeks before mating and during gestation and lactation. The male offspring were placed on either the ND or HF diet from weaning to 4 months of age, resulting in four experimental groups (maternal diet/postweaning diet; n=8-10/group): ND/ND, ND/HF, HF/ND and HF/HF. Another group of HF/HF rats (n=10) was treated with 0.5% resveratrol in drinking water between 2 and 4 months of age (HF/HF+R). Rats were killed at 4 months of age. We found that HF/HF-induced hypertension in adult offspring was prevented by resveratrol. Resveratrol mediated its protective effect on HF/HF-induced hypertension in the kidneys of male offspring by diminishing oxidative stress; reducing renal asymmetric dimethylarginine levels; mediating the renin-angiotensin system (RAS) in favor of vasodilatation; restoring nutrient-sensing pathways via increased levels of silent information regulator transcript 1 (SIRT1), AMP-activated protein kinase 2α and peroxisome proliferator-activated receptor gamma coactivator 1-α; and inducing autophagy. Our data implicated an association between oxidative stress, RAS, nitric oxide, and nutrient-sensing signals in HF/HF-induced hypertension. Resveratrol, acting as an antioxidant as well as a SIRT1 activator, might be a therapeutic approach for hypertension.

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Resveratrol prevents the combined maternal plus postweaning high-fat-diets-induced hypertension in male offspring

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