Resveratrol Regulates Circadian Clock Genes in Rat-1 Fibroblast Cells

Nov 11, 2008Bioscience, biotechnology, and biochemistry

Resveratrol influences daily rhythm genes in rat connective tissue cells

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Abstract

A dose of 100 µM resveratrol regulated the expression of clock genes in Rat-1 cells.

  • Resveratrol is a natural polyphenol that may influence circadian rhythms.
  • The study focused on the effects of food components on peripheral circadian clocks.
  • No cytotoxicity was observed at the tested dose of resveratrol.
  • Regulation of clock genes Per1, Per2, and Bmal1 was noted with resveratrol treatment.

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