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Quercetin, caffeic acid and resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells
Quercetin, caffeic acid, and resveratrol influence daily rhythm and aging genes in young and old human lung cells
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Abstract
Quercetin and caffeic acid increased clock gene expression in old fibroblast cells compared to resveratrol.
- Quercetin enhanced Sirt1 expression, while caffeic acid increased Sirt6 expression, suggesting potential anti-aging effects.
- In young fibroblast cells, both quercetin and caffeic acid demonstrated higher expression of clock-controlled genes (Sirt1 and NR1D1) than resveratrol.
- Caffeic acid may influence NRF2 expression, which is linked to the actions of GRĪ±, GDF11, Sirt1, and Sirt6.
- The activation effect of caffeic acid on Per1 was confirmed to impact NR1D1 expression in young fibroblast cells.
- Findings indicate a connection between circadian clock genes and cellular aging.
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