Diabetes, obesity & metabolism

Retatrutide as a treatment for obesity, sleep apnea, and knee osteoarthritis: Study plan for the TRIUMPH clinical trials

Updated

Abstract

Over 5800 participants are enrolled in the TRIUMPH clinical development program evaluating retatrutide for treating obesity and its complications.

  • Retatrutide is a triple agonist that activates receptors related to insulin and glucagon regulation.
  • The program includes four Phase 3 trials assessing retatrutide against placebo in conjunction with diet and exercise.
  • Primary endpoints include changes in body weight for weight management and specific indices for obstructive sleep apnea and knee osteoarthritis.
  • The trial design allows for independent analysis of treatment effects across multiple obesity-related conditions.

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Funding

Competing interests

Lee M. Kaplan declares providing paid consultation to Altimmune, Amgen, AstraZeneca, Boehringer Ingelheim, Cytoki, Ethicon, Kallyope, The Last Food Fight, Eli Lilly, Neurogastrx, Novo Nordisk, Optum Health, Oxford Medical Products, Perspectum, Pfizer and Sidekick Health. Professor Carel le Roux reports grants from the EU Innovative Medicine Initiative, Irish Research Council, Science Foundation Ireland, Anabio and the Health Research Board. He serves on advisory boards and speakers' panels of Novo Nordisk, Roche, Herbalife, GI Dynamics, Eli Lilly, Johnson & Johnson, Gila, Irish Life Health, Boehringer Ingelheim, Currax, Zealand Pharma, Keyron, AstraZeneca, Arrowhead Pharma, Amgen, AbbVie, Metsera, Nymble, Olympus and Rhythm Pharma. ClR is the Chair of the Irish Society for Nutrition and Metabolism. ClR received stock options as payment for scientific advisory board functions from Metsera and Nymble. ClR provides obesity clinical care in the My Best Weight clinic and Beyond BMI clinic and is a co‐owner of these clinics. David J. Hunter is the editor of the osteoarthritis section for UpToDate and co‐Editor in Chief of Osteoarthritis and Cartilage. DJH provides consulting advice on scientific advisory boards for Haleon, TLCBio, Novartis, Tissuegene, Sanofi and Enlivex. Dr. Virend K. Somers is funded by the National Heart, Lung, and Blood Institute (HL65176, HL168173 and HL160619); has served as a consultant for Jazz Pharmaceuticals, Lilly, Apnimed, Axsome and Mineralys; and is on the Sleep Number Scientific Advisory Board. Kathryn Giblin, Mary Angelyn Bethel, Amy Lalonde, Nadia Ahmad and Qiwei Wu are employees and shareholders of Eli Lilly and Company.
PubMed

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