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REV‐ERBα activates the mTOR signalling pathway and promotes myotubes differentiation
REV-ERBα activates the mTOR pathway and helps muscle cells mature
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Abstract
REV-ERBα promotes myoblast differentiation by activating mTORC1 signaling.
- REV-ERBα is involved in the differentiation of C2C12 myoblasts into myotubes.
- Both mTOR and myogenin levels increase during myoblast differentiation.
- REV-ERBα activates mTORC1 even without differentiation medium.
- This activation may occur through reducing TSC1 expression, which inhibits mTORC1.
- Modulating REV-ERBα could influence myoblast differentiation via mTORC1 signaling.
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