Angiotensin II Suppresses Rev-erbα Expression in THP-1 Macrophages via the Ang II Type 1 Receptor/Liver X Receptor α Pathway

Angiotensin II suppressed Rev-erbα mRNA and protein expression in THP-1 macrophages in a dose and time dependent manner.

• The suppression of Rev-erbα expression was mediated through the Angiotensin II type 1 receptor (AT1R).
• Angiotensin II treatment also downregulated liver X receptor α (LXRα) protein expression over time.
• Manipulating LXRα levels significantly altered Rev-erbα expression in response to Angiotensin II.
• The Rev-erbα agonist SR9009 significantly reduced MMP-9 mRNA and protein expressions induced by Angiotensin II in macrophages.

AI simplified