Levels and roles of Rev-Erbα in different brain areas of mice with short-term and long-term epilepsy

Epileptic seizures show distinct circadian rhythms that may be disrupted during acute status epilepticus and chronic epilepsy.

• Disruption of circadian rhythms may worsen the frequency and severity of seizures.
• Rev-Erbα is identified as a key regulator of circadian rhythms that is significant in the context of epilepsy.
• The expression of Rev-Erbα and its agonist SR9009 is investigated across various brain regions during seizure episodes.
• Understanding the role of Rev-Erbα could provide insights into the mechanisms underlying epilepsy.

Simplified