Rev-erbα regulates circadian rhythms and StAR expression in rat granulosa cells as identified by the agonist GSK4112

Mar 20, 2012Biochemical and biophysical research communications

Rev-erbα controls daily rhythms and hormone-related protein levels in rat ovarian cells using the activator GSK4112

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Abstract

GSK4112 treatment significantly reduced the Per2-dLuc amplitude in mature granulosa cells.

  • Circadian oscillation was detected in mature granulosa cells from antral follicles.
  • GSK4112, an agonist of Rev-erbα, induced a phase advance shift in Per2 oscillation.
  • Bmal1 mRNA expression was significantly inhibited by GSK4112 treatment.
  • StAR mRNA expression was stimulated in a dose-dependent manner by GSK4112.
  • Findings suggest a role for Rev-erbα in coordinating circadian rhythm and metabolism in rat ovaries.

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