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A Specific Role for the REV-ERBα–Controlled L-Type Voltage-Gated Calcium Channel CaV1.2 in Resetting the Circadian Clock in the Late Night
The role of a REV-ERBα-controlled calcium channel in resetting the body’s internal clock late at night
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Abstract
Mice deficient in the Cav1.2 channel showed a significant reduction in their ability to phase-advance circadian behavior after exposure to light in the late night.
- L-type voltage-gated calcium channels (VGCCs) are involved in regulating the internal circadian clock and its response to light.
- Cav1.2 mRNA expression exhibits a rhythmic pattern, peaking during the late night, and is regulated by the circadian clock component REV-ERBα.
- The absence of Cav1.2 affects the induction of clock genes, with notable reductions in Per2 and Per1 during early and late night, respectively.
- These findings suggest that Cav1.2 plays a crucial role in both clock gene expression and the adjustment of circadian rhythms in response to environmental light.
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