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Abstract
Daily rhythms in tissue oxygenation were observed, showing the role of oxygen as a resetting cue for circadian clocks.
- Oxygen levels were continuously measured in living animals, revealing daily cycles in tissue oxygenation.
- Oxygen cycles in the physiological range can synchronize cellular clocks through a specific protein, HIF1α.
- Several clock genes showed responsiveness to changes in oxygen levels via HIF1α.
- A moderate short-term reduction in oxygen levels accelerated adaptation to time changes in wild-type mice but not in those lacking HIF1α.
- Oxygen modulation may serve as a potential therapy for jet lag.
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