How Rhythmic RNA Levels Rise and Fall in Mammals

Rhythmic RNA synthesis and degradation may collectively determine the timing and levels of RNA accumulation in various tissues.

• Circadian RNA expression is often specific to tissues, with some genes showing rhythmic patterns only in certain areas.
• A small number of genes exhibit rhythmic expression across most tissues, suggesting a common regulatory mechanism.
• Both RNA synthesis and degradation need to be rhythmic to create consistent RNA profiles.
• The review explores how the dynamics of RNA processes contribute to the rhythmicity, phase, and amplitude of gene expression.
• RNA degradation may play a significant role in establishing tissue-specific RNA rhythms.

Simplified