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RNA m6A methylation regulates uveal melanoma cell proliferation, migration, and invasion by targeting c‐Met
RNA m6A methylation may control uveal melanoma cell growth and movement by affecting c-Met
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Abstract
Global RNA mA methylation levels were dramatically elevated in both uveal melanoma (UM) cell lines and clinical specimens.
- METTL3, a key enzyme regulating mA methylation, was significantly increased in UM cells and specimens.
- Blocking mA methylation through either cycloleucine or silencing METTL3 suppressed UM cell proliferation and colony formation.
- Inhibition of METTL3 led to cell cycle G1 arrest and reduced migration and invasion of UM cells.
- Overexpression of METTL3 had the opposite effects, promoting UM cell proliferation and invasion.
- c-Met was identified as a direct target of mA methylation in UM cells, with its expression downregulated by inhibiting METTL3.
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