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ALKBH5-mediated m6A demethylation of FOXM1 mRNA promotes progression of uveal melanoma
How ALKBH5 enzyme alters FOXM1 mRNA to promote uveal melanoma growth
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Abstract
ALKBH5 expression was significantly elevated in uveal melanoma (UM) cell lines and is associated with worse outcomes in patients.
- Downregulation of ALKBH5 inhibited tumor growth in UM cell lines.
- Increased ALKBH5 expression was linked to higher rates of UM cell proliferation, migration, and invasion.
- ALKBH5 may promote UM metastasis by inducing changes that enhance cell movement and survival.
- Activation of H3K27 acetylation by EP300 led to increased ALKBH5 expression.
- ALKBH5-induced demethylation of mRNA could facilitate UM progression.
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