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m 6 A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program
ALKBH5 Enzyme Helps Brain Cancer Stem-like Cells Grow by Keeping FOXM1 Active and Supporting Cell Division
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Abstract
ALKBH5 is highly expressed in glioblastoma stem-like cells (GSCs).
- Silencing ALKBH5 suppresses the proliferation of patient-derived GSCs.
- Altered expression of certain target genes was observed following integrated transcriptome and mA-seq analyses.
- ALKBH5 demethylates nascent transcripts of the transcription factor FOXM1, leading to increased FOXM1 expression.
- A long non-coding RNA, FOXM1-AS, promotes the interaction between ALKBH5 and FOXM1 nascent transcripts.
- Depleting both ALKBH5 and FOXM1-AS disrupted tumorigenesis in GSCs through the FOXM1 axis.
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