High expression of AlkB homolog 5 suppresses the progression of non‐small cell lung cancer by facilitating ferroptosis through m6A demethylation of SLC7A11

ALKBH5 expression is low in lung cancer patients.

• Low levels of ALKBH5 are associated with poor outcomes in non-small cell lung cancer (NSCLC).
• Upregulation of ALKBH5 in NSCLC cells is linked to reduced cell proliferation, invasion, and migration, while promoting apoptosis.
• Increasing ALKBH5 levels leads to decreased glutathione and elevated lipid reactive oxygen species, malondialdehyde, and iron ion contents.
• ALKBH5 upregulation results in downregulation of SLC7A11 by reducing its m6A modification.
• The effects of ALKBH5 on ferroptosis and malignant behaviors are partially counteracted by SLC7A11 upregulation.
• In vivo studies indicate that increased ALKBH5 expression suppresses tumor development and lowers GPX4 levels.

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