N6-methyladenosine ALKBH5 promotes non-small cell lung cancer progress by regulating TIMP3 stability

Jan 14, 2020Gene

How ALKBH5 helps non-small cell lung cancer grow by controlling the stability of TIMP3

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Abstract

ALKBH5 is ectopically up-regulated in non-small cell lung cancer (NSCLC) tissue and cells.

  • ALKBH5 expression is closely correlated with poor prognosis in NSCLC patients.
  • ALKBH5 promotes proliferation and reduces apoptosis of NSCLC cells in laboratory settings.
  • Knockdown of ALKBH5 inhibits tumor growth in live models.
  • ALKBH5 targets TIMP3, affecting its mRNA stability and protein production.
  • The study confirms the role of the ALKBH5/TIMP3 pathway in NSCLC development.

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