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ALKBH5 decreases SLC7A11 expression by erasing m6A modification and promotes the ferroptosis of colorectal cancer cells
ALKBH5 lowers SLC7A11 levels by removing m6A marks and helps trigger ferroptosis in colorectal cancer cells
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Abstract
ALKBH5 overexpression in colorectal cancer cells promotes reactive oxygen species release and ferroptosis.
- ALKBH5 is downregulated in colorectal cancer tissues and cells.
- Overexpression of ALKBH5 leads to an increase in reactive oxygen species and promotes ferroptosis in colorectal cancer cells.
- ALKBH5 decreases the stability of SLC7A11 mRNA by removing m6A modifications, which reduces SLC7A11 protein expression.
- SLC7A11 overexpression can counteract the effects of ALKBH5 overexpression on ferroptosis.
- In vivo, upregulation of ALKBH5 reduces tumor growth in mice injected with colorectal cancer cells.
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