We can’t show the full text here under this license. Use the link below to read it at the source.
RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo
RORγ directly controls daily rhythms of clock genes and their related targets in living organisms
AI simplified
Abstract
Lack of γ or α expression in mice resulted in a significant reduction in peak expression levels of clock genes such as Cry1, Bmal1, and Per2.
- RORγ and RORα showed redundancy in regulating clock gene expression in certain tissues.
- RORγ can activate reporter gene activity by binding to regulatory regions of clock genes.
- Co-expression of Rev-Erbα or a ROR antagonist can repress RORγ's activation of these genes.
- RORγ regulates clock genes directly in a time-dependent manner, as shown by DNA binding studies.
- Changes in histone acetylation and chromatin accessibility are associated with ROR-mediated transcriptional activation.
- The rhythmic expression of Avpr1a in the liver is linked to RORγ, suggesting its role in linking circadian rhythms to metabolic gene regulation.
AI simplified
Key numbers
8-fold
Peak Expression Reduction
γ induced promoter activity of Cry1 and Bmal1 8-fold compared to controls.
4 tissues
Tissue-Specific Impact
were analyzed in liver, BAT, WAT, and kidney tissues.