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Abstract
RORA is frequently downregulated in autism spectrum disorder (ASD), impacting several critical biological pathways.
- RORA integrates various biological processes, including hormone signaling, gene regulation, and immune function.
- Its downregulation in ASD is linked to disrupted pathways that affect brain development and synapse formation.
- Androgens suppress RORA expression, while estrogens activate it, which may explain the gender differences in ASD prevalence.
- A feedback loop involving RORA and aromatase promotes androgen dominance and decreases estrogen-related protective effects.
- RORA deficiency could lead to developmental issues in pregnancy, metabolic abnormalities in childhood, and inflammation-related symptoms.
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