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Rotating night shift work and colorectal cancer risk in the nurses’ health studies
Night shift work and the risk of colorectal cancer in nurses
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Abstract
In total, 190,810 women were studied over 24 years to investigate the link between rotating night shift work and colorectal cancer risk.
- No overall association was found between rotating night shift work duration and colorectal cancer risk in the cohorts.
- In the Nurses' Health Study, long-term rotating night shift work (15+ years) was associated with an increased risk of rectal cancer ( 1.60).
- For short to medium durations of rotating night shift work (1-14 years), the risk of rectal cancer did not significantly increase.
- Subsite analysis revealed that while distal colon cancer and proximal colon cancer risks did not show significant increases, rectal cancer risk did increase with longer shift work duration.
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Key numbers
1.60
Rectal Cancer Increase
for rectal cancer in women with 15+ years of night shift work.
1,965
Total Colorectal Cancer Cases
Total colorectal cancer cases documented during 24 years of follow-up.
190,810
Study Cohort Size
Total number of women included from NHS and NHS2.