Rotating night shift work is associated with an increased risk of gastroesophageal reflux disease (GERD) symptoms among workers in China: A cross‐sectional study

Nov 21, 2020International journal of clinical practice

Rotating night shift work linked to higher risk of acid reflux symptoms in Chinese workers

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Abstract

Among 2027 workers, 27.4% reported symptoms of gastroesophageal reflux disease (GERD).

Rotating night shift work is associated with a higher risk of GERD symptoms, with an odds ratio of 3.66.
Age is also a significant factor, with an odds ratio of 2.53 for GERD symptoms.
Smoking presents a strong association with GERD symptoms, indicated by an odds ratio of 3.70.
Helicobacter pylori infection is associated with a decreased risk of GERD symptoms, with an odds ratio of 0.68.
Obesity shows a strong link to GERD symptoms, with an odds ratio of 3.04.
A five-variable model for identifying high-risk individuals for GERD symptoms achieved an area under the ROC curve of 0.80.

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AIMS OF THE STUDY: Increasing studies suggest a significant association between night shift work and an increased risk of type 2 diabetes, obesity and other metabolic disorders. However, the available evidence of the association of rotating night shift work with gastroesophageal reflux disease (GERD) is limited. Herein, we hypothesised a link between the GERD risk and rotating night shift work among workers in China.

METHODS USED TO CONDUCT THE STUDY: A total of 2027 workers who completed a comprehensive health checkup were included. Logistic regression was used to investigate the link between rotating night shift work and the risk of GERD symptoms. Receiver operating characteristic (ROC) curve analysis was used to assess the multivariable model's diagnostic value for identifying GERD symptoms among workers.

RESULTS OF THE STUDY: In total, 556 (27.4%) individuals had GERD symptoms among 2027 workers. Multivariate analysis showed five independent factors for GERD: rotating night shift work (OR = 3.66, 95% CI: 2.52-5.40), age (OR = 2.53, 95% CI: 1.67-3.78), smoking (OR = 3.70, 95% CI: 2.63-5.21), Helicobacter pylori (H. pylori) infection (OR = 0.68, 95% CI: 0.48-0.96) and obesity (OR = 3.04, 95% CI: 2.43-3.83). A five-variable model based on five independent factors provided an area under a ROC curve (AUROC) of 0.80 (95% CI: 0.78-0.81) for identifying GERD symptoms among workers.

CONCLUSIONS DRAWN FROM THE STUDY AND CLINICAL IMPLICATIONS: Rotating night shift work is independently associated with an increased risk of GERD symptoms. Moreover a five-variable model (rotating night shift work, age, smoking, H pyori infection and obesity) can help identify individuals at high risk for GERD symptoms among workers in China.

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Rotating night shift work is associated with an increased risk of gastroesophageal reflux disease (GERD) symptoms among workers in China: A cross‐sectional study

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