Rotating night shift work and non-alcoholic fatty liver disease among steelworkers in China: a cross-sectional survey

Feb 6, 2020Occupational and environmental medicine

Rotating night shift work and risk of fatty liver disease in Chinese steelworkers

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Abstract

Current night shift workers have a 23% higher odds of developing non-alcoholic fatty liver disease (NAFLD) compared to those who never worked night shifts.

Both the duration and cumulative number of night shifts are positively associated with NAFLD.
Higher average frequency of night shifts (>7 nights/month) is linked to increased odds of NAFLD.
Longer average length of night shifts (>8 hours/night) is also associated with higher odds of NAFLD.
No significant associations were observed between night shift work and NAFLD in female steelworkers.

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OBJECTIVES: In a 24/7 society, the negative metabolic effects of rotating night shift work have been increasingly explored. This study aimed to examine the association between rotating night shift work and non-alcoholic fatty liver disease (NAFLD) in steelworkers.

METHODS: A total of 6881 subjects was included in this study. Different exposure metrics of night shift work including current shift status, duration of night shifts (years), cumulative number of night shifts (nights), cumulative length of night shifts (hours), average frequency of night shifts (nights/month) and average length of night shifts (hours/night) were used to examine the relationship between night shift work and NAFLD.

RESULTS: Current night shift workers had elevated odds of NAFLD (OR, 1.23, 95% CI 1.02 to 1.48) compared with those who never worked night shifts after adjustment for potential confounders. Duration of night shifts, cumulative number of night shifts and cumulative length of night shifts were positively associated with NAFLD. Both the average frequency of night shifts (>7 nights/month vs ≤7 nights/month: OR, 1.24, 95% CI 1.06 to 1.45) and average length of night shifts (>8 hours/night vs ≤8 hours/night: OR, 1.27, 95% CI 1.08 to 1.51) were independently associated with overall NAFLD after mutually adjusting for the duration of night shifts and other potential confounders among night shift workers. No significant association was found in female workers between different exposure metrics of night shift work and NAFLD.

CONCLUSIONS: Rotating night shift work is associated with elevated odds of NAFLD in male steelworkers.

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Rotating night shift work and non-alcoholic fatty liver disease among steelworkers in China: a cross-sectional survey

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