Obesity (Silver Spring, Md.)Feb 9, 2022

Comparing three types of weight-loss surgery: Roux-en-Y gastric bypass, sleeve gastrectomy, and one-anastomosis gastric bypass

GLP-1 Therapies Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Apr 6, 2026

Abstract

Roux-en-Y gastric bypass (RYGB) results in greater at 3 years compared to other bariatric procedures.

RYGB patients experienced greater excess weight loss (EWL) at 3 years (mean difference: 11.93) and 5 years (mean difference: 13.11).
Higher excess BMI loss was observed with RYGB at 1 year (mean difference: 11.66).
was significantly higher for RYGB patients at multiple time points: 3 months (mean difference: 2.41), 6 months (mean difference: 3.83), 1 year (mean difference: 6.35), and 5 years (mean difference: 3.90).
No significant difference in rates was found between RYGB and sleeve gastrectomy (SG).
After 1 year, excess weight loss was significantly greater with one-anastomosis gastric bypass (OAGB) than RYGB (mean difference: -10.82).

Simplified

OBJECTIVE: This study aimed to determine which bariatric procedure allows patients to obtain the best weight-loss outcomes and a remission of type 2 diabetes.

METHODS: Databases were searched for randomized-controlled trials comparing Roux-en-Y gastric bypass (RYGB) with sleeve gastrectomy (SG) or one-anastomosis gastric bypass (OAGB). The mean difference (MD) or the relative risk was determined.

RESULTS: Twenty-five randomized-controlled trials were analyzed. (EWL, percentage) was greater for RYGB patients at 3 years (MD: 11.93, p < 0.00001) and 5 years (MD: 13.11, p = 0.0004). Higher excess BMI loss (percentage) was found in RYGB at 1 year (MD: 11.66, p = 0.01). (percentage) was greater for RYGB patients after 3 months (MD: 2.41, p = 0.02), 6 months (MD: 3.83, p < 0.00001), 1 year (MD: 6.35, p < 0.00001), and 5 years (MD: 3.90, p = 0.005). No difference in terms of remission of type 2 diabetes was seen between RYGB and SG. EWL was significantly more important after OAGB than after RYGB after 1 year (MD: -10.82, p = 0.003).

CONCLUSIONS: RYGB is more efficient than SG in the midterm. OAGB offers greater EWL than RYGB after 1 year, but further evidence is needed to confirm this result.

Key numbers

11.93%

Increase in at 3 years

Percentage of excess weight lost after RYGB vs. SG

10.82%

Increase in at 1 year

Mean difference in between OAGB and RYGB

No difference in diabetes remission

Remission of type 2 diabetes rates between RYGB and SG

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Funding

Competing interests

The authors declared no conflict of interest.

PubMed

Comparing three types of weight-loss surgery: Roux-en-Y gastric bypass, sleeve gastrectomy, and one-anastomosis gastric bypass

Abstract

Key numbers

Full Text

Funding

Competing interests

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Abstract

Key numbers

Full Text

Funding

Competing interests

Related papers

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What Lands in Your Inbox Each Week:

Recent issues from the glp-1 therapies brief