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Rumen-derived lipopolysaccharide induced ruminal epithelium barrier damage in goats fed a high-concentrate diet
Bacterial toxins from the stomach lining cause barrier damage in goats fed a high-grain diet
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Abstract
The pH of rumen fluid was lower in goats on a high-concentrate diet compared to those on a low-concentrate diet (P < 0.05).
- A high-concentrate diet is associated with lower expression levels of p38 MAPK, ERK, and JNK in the rumen epithelium compared to a low-concentrate diet (P < 0.05).
- Tight junction protein levels, including claudin-1, claudin-4, occludin, and Zona occludin-1, were greater in the low-concentrate diet group than in the high-concentrate group (P < 0.05).
- Irregular staining patterns of claudin-1, occludin, and ZO-1 were observed in the rumen epithelium of goats fed a high-concentrate diet.
- High-concentrate feeding may impair rumen epithelium function through the MAPK signaling pathway.
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