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Running on mixed fuel‐dual agonistic approach of GLP‐1 and GCG receptors leads to beneficial impact on body weight and blood glucose control: A comparative study between mice and non‐human primates
Activating both GLP-1 and glucagon receptors helps control body weight and blood sugar in mice and primates
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Abstract
A higher loss in body weight was measured in dual agonist-treated obese mice compared to the selective GLP-1R agonist liraglutide.
- Dual agonists significantly improved glycaemic control in both diet-induced obese mice and monkeys.
- Increased total energy expenditure (TEE) and enhanced fat and carbohydrate oxidation were observed with the dual agonist, unlike liraglutide, which showed no effect on TEE.
- Chronic treatment with the monkey-specific dual agonist reduced total energy intake to 60%-70% of baseline levels.
- A decrease in body weight and significant improvement in glucose tolerance were noted in obese and diabetic monkeys.
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Key numbers
21.1%
Body Weight Loss (Mice)
Weight loss percentage in dual agonist-treated mice compared to liraglutide.
8.2%
Body Weight Loss (Monkeys)
Weight loss percentage in monkeys treated with dual agonist.
60%-70%
Total Energy Intake Reduction
Reduction in total energy intake in monkeys during treatment.