S-ketamine as a treatment for suicidal thoughts and hard-to-treat depression in teens with early psychosis

Depressive symptoms and suicidality are highly prevalent in adolescents with early-onset psychosis.

• Adolescents with early-onset psychosis may experience symptoms of depression and suicidal thoughts more frequently than their peers.
• Standard treatments often do not adequately address these depressive symptoms in this population.
• S-ketamine is known to be effective for treatment-resistant depression in adults.
• The potential use of S-ketamine in adolescents with primary psychotic disorders is limited due to concerns about worsening psychotic symptoms.

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