Open forum infectious diseases

Safety and Immune Response to the BNT162b2 Vaccine in People With HIV on Antiretroviral Treatment

Updated

Abstract

The safety and immunogenicity of a 2-dose regimen of the mRNA vaccine BNT162b2 is being evaluated in people with human immunodeficiency virus (HIV) on antiretroviral therapy.

  • People with HIV are at greater risk for severe COVID-19.
  • Priority vaccination is recommended for individuals with HIV.
  • The study focuses on individuals receiving antiretroviral therapy.
  • Increased safety and immune response could be critical for this population.

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Full Text

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Funding

Competing interests

Potential conflicts of interest. J. A. has received institutional research support from Pfizer during the conduct of this clinical trial. J.A. also reports institutional support from Gilead Sciences, GlaxoSmithKline, Janssen, Macrogenics, Merck, Pfizer, Regeneron, and ViiV Healthcare; personal fees for advisory boards from GlaxoSmithKline/ViiV, Invivyd, Merck, and Regeneron; and participation on a data and safety monitoring board for Kintor Pharmaceuticals, all outside the submitted work. M. J. G. T. V. has received grants or contracts from Heel, MSD, Roche, and Tillotts; consulting fees from Bioaster, Ferring, Gilead, Pfizer, and Tillotts; and honoraria from the Academy for Infectious Diseases, AstraZeneca, bioMérieux, DGI, the European Society of Neurogastroenterology, Falk Foundation, Ferring, FomF GmbH, Malteser Förderkreis, Frankfurt Citizens University, Gilead, GSK, Helios Kliniken, Hessian State Social Court, Infection Forum, Janssen-Cilag GmbH, Jörg Eikerle Consulting, Kassel Hospital, Lahn-Dill Kliniken, Hessian Medical Association, LMU Kliniken, MSD, Pfizer, Streamed up, St. Vincent Hospital, and Tillotts. C. S. has received grants or contracts from the German Ministry for Economic Cooperation and Development, and the Society for Intercultural Cooperation; consulting fees and/or honoraria from Gilead, Janssen-Cilag, MSD, Shionogi, and ViiV Healthcare; payment for expert testimony from Marburg and Berlin District Courts; and support for meeting attendance from AbbVie, Gilead, Janssen-Cilag, and MSD. E. M. A. was previously employed by BioNTech, has received consulting fees from Quigley BioPharma, and is a National Institutes of Health Special Volunteer. N. K., R. B., T. J. B., W. C. G., S. M., K. S., J. T. P., C. W., X. X., and A. G. are current/former employees at Pfizer and may hold Pfizer stock and stock options. S. P. L. was previously employed by Pfizer, holds stock in Pfizer, and has received consulting fees from Pfizer. Ö. T. and U. Ş. are management board members and employees at BioNTech. I. V., S. F., J. Q., M.-C. K., A. M., B. G. L., M. B., S. L., E. L., and S. S. are current/former employees at BioNTech and may hold BioNTech stock and stock options. E. M., M. B., C. J. L., and F. C. were investigators of the study. All other authors report no potential conflicts.
PubMed

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