Concise Review: Salivary Gland Regeneration: Therapeutic Approaches from Stem Cells to Tissue Organoids

Jul 14, 2016Stem cells (Dayton, Ohio)

Salivary Gland Repair: Treatments from Stem Cells to Lab-Grown Tissue

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Abstract

Several strategies have been proposed for restoring salivary gland function in patients with dry mouth syndrome.

  • Transplanting autologous salivary gland-derived epithelial stem or progenitor cells may aid in restoring gland function.
  • Utilizing non-epithelial cells and their bioactive materials could potentially contribute to salivary gland repair.
  • Tissue engineering approaches that incorporate three-dimensional biomaterials with salivary gland cells may mimic natural gland structures.
  • Advancements in these strategies may lead to effective therapies for repairing damaged salivary glands.
  • Development of miniature salivary gland organoids is associated with the fundamental restoration of saliva secretion.

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