Sedation and active body clock patterns in ventilated patients in intensive care

Sedation with a stimulative circadian rhythm resulted in 19 patients recovering normal circadian rhythm after weaning, compared to 9 in continuous sedation.

• Sedation protocols showed no differences in age, sex ratio, body weight, or APACHE II scores among the circadian rhythm, daily interruption, and continuous sedation groups.
• Total sedative dosages were significantly higher in the continuous sedation group compared to the circadian rhythm and daily interruption groups.
• Daily arousal time was significantly longer in the circadian rhythm group compared to the daily interruption and continuous sedation groups.
• Incidences of untoward reactions were higher in the daily interruption group compared to the circadian rhythm and continuous sedation groups.
• No significant differences in complications or biochemical indicators were observed across groups.

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