How SEDT2/METTL14-related m6A methylation may trigger low-oxygen lung artery high blood pressure in mice

Elevated expression of SETD2 and METTL14 is observed in pulmonary artery smooth muscle cells of hypoxia-induced PAH mice.

• The lack of SETD2 in smooth muscle cells protects mice from hypoxia-induced pulmonary arterial hypertension.
• Significant reductions in right ventricular systolic pressure and heart weight ratios are noted in SETD2 knockout mice.
• Absence of SETD2 also lowers METTL14 expression and mA RNA methylation levels in pulmonary artery smooth muscle cells.
• These findings suggest that inhibiting SETD2/METTL14 activity may offer potential treatment options for PAH.

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