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Effects of once‐weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity
Once-weekly semaglutide's effects on appetite, eating behavior, food choices, and weight in people with obesity
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Abstract
Semaglutide treatment resulted in a 24% reduction in total energy intake across all meals compared with placebo.
- Subjects experienced a mean body weight loss of 5.0 kg after 12 weeks of semaglutide treatment.
- Ad libitum energy intake was significantly lower during lunch, evening meals, and snacks when treated with semaglutide.
- Fasting appetite scores improved with semaglutide, indicating reduced hunger and food cravings.
- Participants showed better control of eating behaviors and a decreased preference for high-fat foods.
- Resting metabolic rate did not change between semaglutide and placebo treatments.
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Key numbers
-3036 kJ
Total Energy Intake Reduction
Total energy intake across all meals with semaglutide vs placebo
-5.0 kg
Body Weight Change
Mean body weight change after 12 weeks of semaglutide treatment vs placebo
-1255 kJ
Lunch Energy Intake Reduction
Energy intake during lunch with semaglutide vs placebo